The department was founded in 1985 and was originally called Therapy-Sh. The department was headed by Doctor of Medical Sciences, Professor Nazhim Kayumovich Bobokhujaev .

During his career, N.K. Babakhodzhaev organized the course “Adolescent Pathology”. The department carried out active work on extragenital pathology, 4 candidate's theses were defended.

Doctor of Medical Sciences, prof. Sh.N. Nosirov was appointed .

Since 2011, the department has been called “Internal Medicine and Pharmacotherapy”. In this regard, more attention was paid to pharmacotherapy in educational programs.

In 2017-2018, the department was headed by Professor Kayumov U.K. was merged with the Department of Internal Diseases, headed by Dr.

In May 2018, the department was divided into two departments: “Internal diseases No. 1” and “Internal diseases No. 2”. Ph.D., Ibragimov A. Yu. appointed.

In September 2023, the departments of “Internal Diseases No. 1” and “Internal Diseases No. 2” were again merged and the Department of Internal Diseases, Ph.D., A.V. Ibragimov, was created. Yu was appointed head of the department.